International Journal of Innovative Research in Health Science

Background: Polycystic Ovary Syndrome is a widespread hormonal condition among women of reproductive age, featuring elevated androgens, irregular ovulation, insulin resistance, and linked metabolic disruptions. Aim: This systematic review and meta-analysis assessed the impact of lifestyle interventions—diet, exercise, pharmacotherapy, and digital tools—on metabolic, reproductive, and quality-of-life parameters in PCOS patients. Methodology: Adhering to PRISMA guidelines, RCTs from 2010–2024 were sourced from various database, extracting data on BMI, waist circumference, HOMA-IR, glucose, ovulation, menstrual regularity, hormones, and quality of life. Results: Of 104 records, 11 studies qualified after screening; meta-analysis revealed significant gains in BMI , insulin sensitivity, ovulation and cycle regularity. Pharmacotherapy-lifestyle combinations excelled in BMI/waist reductions versus lifestyle alone, with apps enhancing diet/exercise adherence amid study heterogeneity. Conclusion: Structured diet, exercise, drugs, and technology prove essential for PCOS management, favoring personalized tech-aided strategies to boost metabolic, reproductive, and psychosocial outcomes; long-term safety trials remain needed.